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Photochemotherapy: Light-Dependent Therapies in Medicine

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Edward P. Zovinka and Danielle R. Sunseri

Deptartment of Chemistry, Mathematics, and Physical Science, Saint Francis University, Loretto, PA 15940

J. Chem. Educ., 2002, 79 (11), p 1331

DOI: 10.1021/ed079p1331

Publication Date (Web): November 1, 2002

Section:

History, Education, and Documentation

Abstract

Light-dependent therapies, such as photodynamic therapy and extracorporeal photopheresis, are not new, but have remained of interest to chemists and health care professionals since the middle of the twentieth century. While most people link light-dependent therapies only to the treatment of cancer, these therapies may be of use for a diverse set of medical conditions, from acne to AIDS. The techniques arise directly from the application of chemical concepts, such as spectroscopy, MO theory, and organic chemical reactions. Because of its application to health care, the field of photochemistry provides a tool to demonstrate the significance of chemistry to a socially important issue.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Public Understanding / Outreach

Keywords (Feature):

Products of Chemistry

Keywords (Subject):

Bioorganic Chemistry

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Tunable DNA Photocleavage by an Acridine−Imidazole Conjugate
Beth Wilson, Lourdes Gude, María-José Fernández, Antonio Lorente, and Kathryn B. Grant
Inorganic Chemistry2005 44 (18), 6159-6173
- Tunable DNA Photocleavage by an Acridine−Imidazole Conjugate
  Beth Wilson, Lourdes Gude, María-José Fernández, Antonio Lorente, and Kathryn B. Grant
  Inorganic Chemistry2005 44 (18), 6159-6173
  The synthesis and DNA-photocleaving properties of a 3,6-acridinediamine chromophore centrally attached to four metal-coordinating imidazoles are reported. Nicking assays of pUC19 plasmid DNA reacted with this acridineimidazole conjugate reveal that the ...
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