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Chemistry under the Microscope—Lab-on-a-Chip Technologies

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Coulton H. Legge

Applied Technology, GlaxoSmithKline Research and Development, Ware, Hertfordshire SG12 0DP, UK

J. Chem. Educ., 2002, 79 (2), p 173

DOI: 10.1021/ed079p173

Publication Date (Web): February 1, 2002

Section:

History, Education, and Documentation

Abstract

Over the past decade the chemical, and in particular the pharmaceutical industry, has experienced a tremendous push toward miniaturization. No longer are we content to carry out chemistries in test tubes or 96-well microtiter plates, but are now utilizing 384-well plates and looking towards 1536 high-density formats, which occupy the same footprint area as a 96-well plate. So called lab-on-a-chip systems are taking the technology one step further--they allow integration of several components into the micro world, to an extent that has not been possible before. Based on the author's work in the pharmaceutical research and development industry, this article focuses on the application of lab-on-a-chip in chemical synthesis and analysis, explores some of its possibilities, and cites some work in the field. The content is targeted to university educators, primarily, and students.

Keywords (Audience):

General Public

Keywords (Domain):

Analytical Chemistry

Keywords (Feature):

Products of Chemistry

Keywords (Subject):

Drugs / Pharmaceuticals

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This article has been cited by 2 ACS Journal articles (2 most recent appear below).

Visualizing Chemical Phenomena in Microdroplets
Sunghee Lee and Joseph Wiener
Journal of Chemical Education2011 88 (2), 151-157
- Visualizing Chemical Phenomena in Microdroplets
  Sunghee Lee and Joseph Wiener
  Journal of Chemical Education2011 88 (2), 151-157
  Phenomena that occur in microdroplets are described to the undergraduate chemistry community. Droplets having a diameter in the micrometer range can have unique and interesting properties, which arise because of their small size and, especially, their ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Micromixer-Based Time-Resolved NMR: Applications to Ubiquitin Protein Conformation
Masaya Kakuta, Dimuthu A. Jayawickrama, Andrew M. Wolters, Andreas Manz, and Jonathan V. Sweedler
Analytical Chemistry2003 75 (4), 956-960
- Micromixer-Based Time-Resolved NMR: Applications to Ubiquitin Protein Conformation
  Masaya Kakuta, Dimuthu A. Jayawickrama, Andrew M. Wolters, Andreas Manz, and Jonathan V. Sweedler
  Analytical Chemistry2003 75 (4), 956-960
  Time-resolved NMR spectroscopy is used to study changes in protein conformation based on the elapsed time after a change in the solvent composition of a protein solution. The use of a micromixer and a continuous-flow method is described where the contents ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links