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Modeling the Drug Discovery Process: The Isolation and Biological Testing of Eugenol from Clove Oil

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Patricia M. Smiley

Southern Lehigh High School, Center Valley, PA 18034

William H. Miles

Department of Chemistry, Lafayette College, Easton, PA 18042

J. Chem. Educ., 2002, 79 (1), p 90

DOI: 10.1021/ed079p90

Publication Date (Web): January 1, 2002

Abstract

This experiment describes the isolation and biological testing of eugenol and neutral compounds from commercially available clove oil. By coupling the chemical separation of the components of clove oil (an experiment described in many introductory organic laboratory textbooks) with a simple antibiotic test, the students "discover" the biologically active compound in clove oil. This experiment models one of the primary methods used in the discovery of new pharmaceutical agents.

Keywords (Audience):

High School / Introductory Chemistry

Keywords (Domain):

Laboratory Instruction

Keywords (Feature):

Second-Year and AP Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Acids / Bases

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Received: August 03, 2009

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Article

Modeling the Drug Discovery Process: The Isolation and Biological Testing of Eugenol from Clove Oil

Abstract

Keywords (Audience):

Keywords (Domain):

Keywords (Feature):

Keywords (Pedagogy):

Keywords (Subject):

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SciFinder Links

History

Recommend & Share

Related Content

Isolation of oil of clove and separation of eugenol and acetyl eugenol. An instructive experiment for beginning chemistry undergraduates

Chemical Composition and Antioxidant Properties of Clove Leaf Essential Oil

Synthesis of a 7-Oxanorbornene Monomer: A Two-Step Sequence Preparation for the Organic Laboratory

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