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Transfer Free Energy and the Hydrophobic Effect

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Joseph M. Serafin

Department of Chemistry, University of Southern Alabama, Mobile, AL 36688-0002

J. Chem. Educ., 2003, 80 (10), p 1194

DOI: 10.1021/ed080p1194

Publication Date (Web): October 1, 2003

Abstract

This laboratory experiment involves making transfer free energy measurements of probe hydrophobic molecules (toluene) in the presence of solubility modifying agents (cosolvents) commonly used in protein science. Important solution thermodynamic quantities such as activity, chemical potential, and the hydrophobic effect are discussed. This laboratory exercise is intended for students in a physical chemistry or biophysical chemistry course. The transfer free energy is determined by spectroscopic solubility measurements of the toluene in the various solutions.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Physical Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Biophysical Chemistry

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