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Using Mass Spectrometry for Proteins
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Abstract
The 2002 Chemistry Nobel Prize has mass spectrometrists everywhere celebrating. It recognizes work that put large proteins, 10,000 Da and up, into mass spectrometers. A description of Koichi Tanaka's experiments using laser desorption ionization and John B. Fenn's experiments using electrospray ionization is given along with a brief summary with references to previous researchers' work that Tanaka and Fenn were familiar with. The techniques Tanaka and Fenn used for their Prize-winning work—techniques that have revolutionized mass spectrometry—have yet to reach current chemistry textbooks, whatever their level.
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Report: Nobel Prize in Chemistry, 2002Keywords (Subject):
Instrumental MethodsCiting Articles
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This article has been cited by 7 ACS Journal articles (5 most recent appear below).
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Danny H. Kim, Curtis D. Eckhert, Kym F. FaullJournal of Chemical Education2011 88 (1), 106-110Mass spectrometry (MS) is a powerful analytical technique that is now widely used in the chemical, physical, engineering, and life sciences, with rapidly growing applications in many areas including clinical, forensic, pharmaceutical, and environmental ...
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Isaac J. Arnquist and Douglas J. BeussmanJournal of Chemical Education2009 86 (3), 382Mass spectrometry has become a routine analytical tool in the undergraduate curriculum in the form of GC–MS. While relatively few undergraduate programs have incorporated biological mass spectrometry into their programs, the importance of these techniques,...
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Nancy Carter Dopke and Timothy Neal LovettJournal of Chemical Education2007 84 (12), 1968Mass spectrometry is a widely used and versatile tool for scientists in many different fields. Soft ionization techniques such as matrix-assisted laser desorption/ionization (MALDI) allow for the analysis of biomolecules, polymers, and clusters. This ...
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Isaac J. Arnquist and Douglas J. BeussmanJournal of Chemical Education2007 84 (12), 1971Biological mass spectrometry is an important analytical technique in drug discovery, proteomics, and research at the biology–chemistry interface. Currently, few hands-on opportunities exist for undergraduate students to learn about this technique. With ...
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- Received: August 03, 2009
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