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A General Chemistry Laboratory Theme: Spectroscopic Analysis of Aspirin
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Abstract
In this paper, we describe the introduction of spectroscopy into the general chemistry laboratory using a series of experiments based on a common substance, aspirin. In the first lab the students synthesize and recrystallize aspirin and take melting points of their product, an aspirin standard, and salicylic acid. The students perform the remaining experiments on a rotating basis where the following four labs run simultaneously: structural characterization of the synthesized aspirin by IR and NMR; analysis of synthesized aspirin and commercial products by UV–vis spectroscopy; analysis of synthesized aspirin and commercial products by HPLC; and analysis of calcium in commercial buffered aspirin tablets by AAS. In each of the analysis experiments, students collect, graph, and analyze their data using a spreadsheet. We have found that this series of labs has been very beneficial to our students. From the course evaluations, students indicate that they are beginning to understand how chemistry is applied outside of the classroom.
Keywords (Audience):
First-Year Undergraduate / GeneralKeywords (Domain):
Laboratory InstructionKeywords (Pedagogy):
Inquiry-Based / Discovery LearningKeywords (Subject):
Drugs / PharmaceuticalsCiting Articles
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This article has been cited by 5 ACS Journal articles (5 most recent appear below).
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- Received: August 03, 2009
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