Benzoin Condensation: Monitoring a Chemical Reaction by High-Pressure Liquid Chromatography

Apurba Bhattacharya , Vikram C. Purohit and Nicholas R. Beller
Department of Chemistry, Texas A&M University–Kingsville, Kingsville, TX 78363
J. Chem. Educ., 2004, 81 (7), p 1020
DOI: 10.1021/ed081p1020
Publication Date (Web): July 1, 2004
History, Education, and Documentation

Abstract

High-pressure liquid chromatography was successfully introduced in the undergraduate advanced organic chemistry laboratory to reinvestigate the cyanide-catalyzed condensation of benzaldehyde to benzoin. In addition to an increase in overall yield and purity of the product over the existing procedure the experiment provided the students with a practical hands-on introduction to modern HPLC and its application in process optimization.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Organic Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

HPLC
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  • Received: August 03, 2009

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