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A Simplified Calculation of the Real Confidence Interval in Analytical Methods

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Javier Galbán

GEAS, Analytical Chemistry Department, Faculty of Sciences, University of Zaragoza, 50009 Zaragoza, Spain

J. Chem. Educ., 2004, 81 (7), p 1053

DOI: 10.1021/ed081p1053

Publication Date (Web): July 1, 2004

Section:

History, Education, and Documentation

Abstract

This paper describes a detailed study of the imprecision of an analytical method resulting from the quantification step. Students use a mathematical model we developed to discover the effect of the different parameters on this imprecision. After applying this method with students we reached three main conclusions. First, the imprecision does not depend on the slope of the calibration line. Second, the imprecision does depend on the number (n) and the concentration of the calibration standards used, the analyte concentration in the sample to be analyzed, and the correlation coefficient (r) of the calibration line. Third, when the concentration of the calibration standards are equally spaced and the analyte concentration in the sample is close to the centroid of the line, the imprecision depends only on the n and r values. This model allows students to calculate imprecision more easily so that they will be able to apply this mathematical model both in their studies and their future professional activities.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Analytical Chemistry

Keywords (Feature):

Chemical Education Research

Keywords (Subject):

Quantitative Analysis

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