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Article

One-Pot Synthesis of 7-Hydroxy-3-carboxycoumarin in Water

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Francesco Fringuelli , Oriana Piermatti and Ferdinando Pizzo

Dipartimento di Chimica, Università di Perugia, 8 - 06123 Perugia, Italy

J. Chem. Educ., 2004, 81 (6), p 874

DOI: 10.1021/ed081p874

Publication Date (Web): June 1, 2004

Abstract

7-Hydroxy-3-carboxycoumarin is prepared by a one-pot consecutive process, carried out in water, starting from 2,4-dihydroxybenzaldehyde and malononitrile. The procedure highlights the advantages of using an aqueous medium, particularly the possibility of controlling the pH and isolating the reaction product without using any organic solvent.

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History

Received: August 03, 2009

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Article

One-Pot Synthesis of 7-Hydroxy-3-carboxycoumarin in Water