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One-Pot Synthesis of 7-Hydroxy-3-carboxycoumarin in Water
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Abstract
7-Hydroxy-3-carboxycoumarin is prepared by a one-pot consecutive process, carried out in water, starting from 2,4-dihydroxybenzaldehyde and malononitrile. The procedure highlights the advantages of using an aqueous medium, particularly the possibility of controlling the pH and isolating the reaction product without using any organic solvent.
Keywords (Audience):
Second-Year UndergraduateKeywords (Domain):
Organic ChemistryKeywords (Feature):
Green ChemistryKeywords (Pedagogy):
Hands-On Learning / ManipulativesKeywords (Subject):
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- Received: August 03, 2009
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