Chemical Aspects of Local and Regional Anesthesia

Daryl L. Ostercamp
Department of Chemistry, Concordia College, Moorhead, MN 56562
Robert Brunsvold
Department of Anesthesiology, Meritcare, Fargo, ND 58123
J. Chem. Educ., 2006, 83 (12), p 1816
DOI: 10.1021/ed083p1816
Publication Date (Web): December 1, 2006

Abstract

The chemistry that underlies the development of local and regional anesthesia is explored. Starting from the first medicinal use of cocaine as a topical anesthetic in 1884, the gradual advancement of knowledge and practice until today is presented. In so far as possible, the original synthesis of each agent is included. Emphasis is placed upon the importance of acidity constants and lipophilic versus hydrophilic character in interpreting what affect a particular compound has upon biological processes. Two examples of current hospital practices are included.

Keywords (Audience):

Continuing Education

Keywords (Domain):

History / Philosophy

Keywords (Pedagogy):

Analogies / Transfer

Keywords (Subject):

Acids / Bases
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  • Received: August 03, 2009

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