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Introduction to the Design and Optimization of Experiments Using Response Surface Methodology. A Gas Chromatography Experiment for the Instrumentation Laboratory

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Patricia L. Lang , Benjamin I. Miller and Abigail Tuttle Nowak

Department of Chemistry, Ball State University, Muncie, IN 47306

J. Chem. Educ., 2006, 83 (2), p 280

DOI: 10.1021/ed083p280

Publication Date (Web): February 1, 2006

Section:

History, Education, and Documentation

Abstract

Several experimental design and optimization techniques, such as fractional factorial designs and response surface methodology, are becoming more widely used in chemical research and industry. Yet, the typical chemistry major is likely to be unfamiliar with any of these. We describe a gas chromatography experiment, designed for the senior-level instrumental analysis laboratory, in which the students apply response surface methodology to determine the optimum set of chromatographic conditions required to separate four fatty acid methyl esters.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Analytical Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Chemometrics

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