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GC–MS Analysis of gamma-Hydroxybutyric Acid Analogs

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Colin Henck and Luke Nally

Department of Chemistry and The Northeast Regional Forensic Institute, University at Albany, Albany, NY 12222

J. Chem. Educ., 2007, 84 (11), p 1813

DOI: 10.1021/ed084p1813

Publication Date (Web): November 1, 2007

Section:

History, Education, and Documentation

Abstract

An upper-division forensic chemistry experiment is described. It involves using glycolic acid and sodium glycolate as analogs of γ-hydroxybutyric acid and its sodium salt. The experiment shows the use of silylation in GC–MS analysis and gives students the opportunity to work with a commonly used silylating reagent, N,O-bis[trimethylsilyl]trifluoroacetamide (BSTFA). GC–MS is used to show the problem with analyzing an organic acid without derivatization and to analyze the products of silylation.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Analytical Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Drugs / Pharmaceuticals

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