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General Acid and General Base Catalysis
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General catalysis is indicated when the rate of a reaction depends upon buffer concentration and pH; it is most likely to be observed when the pH of the solution is near the pKa of the buffer and the reaction mechanism involves proton transfer in the rate-determining step.
Keywords (Audience):
Graduate Education / ResearchKeywords (Domain):
Organic ChemistryKeywords (Feature):
LettersKeywords (Subject):
Acids / BasesCiting Articles
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).
Telling It Like It Is: Teaching Mechanisms in Organic Chemistry
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Addison AultJournal of Chemical Education2010 87 (9), 937-941In this article I support and extend the ideas presented by J. Brent Friesen in his article Saying What You Mean; Teaching Mechanisms in Organic Chemistry (JCE November, 2008). I emphasize “telling the truth” about proton transfers. The truth is that in ...
Representing Fractional Distributions in Chemistry
Addison AultJournal of Chemical Education2008 85 (10), 1432Representing Fractional Distributions in Chemistry
Addison AultJournal of Chemical Education2008 85 (10), 1432Many phenomena in chemistry involve fractional distributions. Sometimes it is a chemical substance that is fractionally distributed, other times it is a chemical process that is fractionally distributed. The purpose of this paper is to present a common ...
Frank Westheimer's Early Demonstration of Enzymatic Specificity
Addison AultJournal of Chemical Education2008 85 (9), 1246Frank Westheimer's Early Demonstration of Enzymatic Specificity
Addison AultJournal of Chemical Education2008 85 (9), 1246In this article I review one of the most significant accomplishments of Frank H. Westheimer, one of the most respected chemists of the 20th century. This accomplishment was a series of stereospecific enzymatic oxidation and reduction experiments that led ...
The Rate of Proton Transfer
Eugene E. KwanJournal of Chemical Education2007 84 (1), 39The Rate of Proton Transfer
Eugene E. KwanJournal of Chemical Education2007 84 (1), 39The action of general catalysis should be inferred if the rate of reaction is increased when the buffer concentration is increased at constant pH. This is likely when the pH is near the pKa of the buffer, the degree of protonation in the transition state ...
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- Received: August 03, 2009
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