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Letter

The Rate of Proton Transfer

Eugene E. Kwan

Department of Chemistry, Harvard University, Cambridge, MA 02138

J. Chem. Educ., 2007, 84 (1), p 39

DOI: 10.1021/ed084p39

Publication Date (Web): January 1, 2007

Abstract

The action of general catalysis should be inferred if the rate of reaction is increased when the buffer concentration is increased at constant pH. This is likely when the pH is near the pKa of the buffer, the degree of protonation in the transition state is partial, and when proton transfer is slow, yet compensated by the increased reactivity of the conjugate acid of the reactant.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Organic Chemistry

Keywords (Feature):

Letters

Keywords (Pedagogy):

Misconceptions / Discrepant Events

Keywords (Subject):

Acids / Bases

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History

Received: August 03, 2009

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Letter

The Rate of Proton Transfer

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General Acid and General Base Catalysis

Determination of Proton Transfer Rates by Chemical Rescue: Application to Bacterial Reaction Centers

Factors Affecting the Relative Efficiency of General Acid Catalysis

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