Introducing Michaelis–Menten Kinetics through Simulation

Russell Herman
Department of Mathematics and Statistics, University of North Carolina at Wilmington, Wilmington, NC 28403-3297
Christopher J. Halkides
Department of Chemistry and Biochemistry, University of North Carolina at Wilmington, Wilmington, NC 28403-3297
J. Chem. Educ., 2007, 84 (3), p 434
DOI: 10.1021/ed084p434
Publication Date (Web): March 1, 2007

Abstract

We describe a computer tutorial that introduces the concept of the steady state in enzyme kinetics. The tutorial allows students to produce graphs of the concentrations of free enzyme, enzyme–substrate complex, and product versus time in order to learn about the approach to steady state. By using a range of substrate concentrations and rate constants, students are able to simulate enzyme kinetics and produce Lineweaver–Burk plots. The tutorial is intended for use in third- or fourth-year undergraduate biochemistry courses.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Biochemistry

Keywords (Pedagogy):

Computer-Based Learning

Keywords (Subject):

Biophysical Chemistry
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  • Received: August 03, 2009

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