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Letter

Quantitative Determination of DNA–Ligand Binding: Improved Data Analysis

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Todd P. Silverstein

Department of Chemistry, Willamette University, Salem, OR 97301

J. Chem. Educ., 2008, 85 (9), p 1192

DOI: 10.1021/ed085p1192.2

Publication Date (Web): September 1, 2008

Section:

History, Education, and Documentation

Abstract

Eamonn Healy recently published in this Journal a fine undergraduate biochemistry laboratory project on the binding of the fluorescent ligand DAPI (4,6-diamidino-2-phenylindole) to DNA. For the benefit of faculty who plan to adopt this unique project, I would like to make a few suggestions to improve the data analysis.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Biochemistry

Keywords (Feature):

Letters

Keywords (Pedagogy):

Communication / Writing

Keywords (Subject):

Kinetics

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Nonlinear and Linear Regression Applied to Concentration versus Time Kinetic Data from Pinhas’s Sanitizer Evaporation Project
Todd P. Silverstein
Journal of Chemical Education2011 88 (11), 1589-1590
- Nonlinear and Linear Regression Applied to Concentration versus Time Kinetic Data from Pinhas’s Sanitizer Evaporation Project
  Todd P. Silverstein
  Journal of Chemical Education2011 88 (11), 1589-1590
  A recent article in this Journal described a laboratory experiment in which students study the evaporation kinetics of hand sanitizer. In this communication, the differences between using linear regression on linearized kinetics data versus nonlinear ...
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