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Article

Synthesis of the Commercial Antidepressant Moclobemide

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Jesse D. More

Department of Chemistry, Loyola College, Baltimore, MD 21210

J. Chem. Educ., 2008, 85 (10), p 1424

DOI: 10.1021/ed085p1424

Publication Date (Web): October 1, 2008

Abstract

An experiment for the undergraduate organic chemistry laboratory is described in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix. This one-step synthesis starts from commercially available material and produces moclobemide in high yield. The product is initially isolated as its hydrochloride salt via precipitation. After recrystallization and treatment with base moclobemide is isolated in pure form. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy.

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Received: August 03, 2009

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Article

Synthesis of the Commercial Antidepressant Moclobemide

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Iodolactonization of 4-Pentenoic Acid

Discovery-Oriented Approach To Organic Synthesis: Tandem Aldol Condensation-Michael Addition Reactions. Identifying Diastereotopic Hydrogens in an Achiral Molecule by NMR Spectroscopy

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