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Synthesis of Albendazole Metabolite: Characterization and HPLC Determination
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Abstract
In this laboratory activity, students are introduced to the synthesis of an albendazole metabolite obtained by a sulfide oxidation reaction. Albendazole as well as its metabolite, albendazole sulfoxide, are used as anthelmintic drugs. The oxidation reagent is H2O2 in acetic acid. The reaction is environmental friendly, fast, and proceeds with high yield. The crude reaction is analyzed by HPLC chromatography to determine purity. The simplicity of the experiment allows students to study chiral concepts, physicochemical and spectroscopic properties of the compounds, and HPLC determinations.
Keywords (Audience):
Second-Year UndergraduateKeywords (Domain):
Analytical ChemistryKeywords (Pedagogy):
Hands-On Learning / ManipulativesKeywords (Subject):
Chirality / Optical ActivityCiting Articles
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This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Molecular Models of Peroxides and Albendazoles
William F. ColemanJournal of Chemical Education2008 85 (12), 1710Molecular Models of Peroxides and Albendazoles
William F. ColemanJournal of Chemical Education2008 85 (12), 1710This month's Featured Molecules are albendazole and benzoyl peroxide.
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History
- Received: August 03, 2009
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