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A Simple Experiment in the Separation of a Solid-Phase Mixture and Infrared Spectroscopy for Introductory Chemistry
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Abstract
This experiment was developed as a means of incorporating instrumental analyses into an introductory chemistry laboratory. A two-component solid mixture of caffeine and ibuprofen is separated through a series of solution extractions and precipitation and their relative amounts measured. These compounds were chosen because the combination of caffeine and ibuprofen as an oral suspension has recently been investigated for pain relieving capabilities superior to those of ibuprofen alone providing a real-world context to the experiment. The solid components once recovered, dried, and weighed are analyzed using infrared spectrophotometry (IR). The goal of the IR analysis is to determine how effectively the two components were separated by comparing their spectra with the known spectra of the pure components. A guided-inquiry approach is utilized throughout the procedure for this experiment.
Keywords (Audience):
First-Year Undergraduate / GeneralKeywords (Domain):
Laboratory InstructionKeywords (Pedagogy):
Hands-On Learning / ManipulativesKeywords (Subject):
Acids / BasesCiting Articles
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This article has been cited by 3 ACS Journal articles (3 most recent appear below).
Examination of Bond Properties through Infrared Spectroscopy and Molecular Modeling in the General Chemistry Laboratory
Clifford M. Csizmar, Dee Ann Force, and Don L. WarnerJournal of Chemical Education2012 Article ASAPExamination of Bond Properties through Infrared Spectroscopy and Molecular Modeling in the General Chemistry Laboratory
Clifford M. Csizmar, Dee Ann Force, and Don L. WarnerJournal of Chemical Education2012 Article ASAPA concerted effort has been made to increase the opportunities for undergraduate students to address scientific problems employing the processes used by practicing chemists. As part of this effort, an infrared (IR) spectroscopy and molecular modeling ...
Quantitative Investigations of Biodiesel Fuel Using Infrared Spectroscopy: An Instrumental Analysis Experiment for Undergraduate Chemistry Students
Andrew P. Ault and Robert PomeroyJournal of Chemical Education2012 89 (2), 243-247Quantitative Investigations of Biodiesel Fuel Using Infrared Spectroscopy: An Instrumental Analysis Experiment for Undergraduate Chemistry Students
Andrew P. Ault and Robert PomeroyJournal of Chemical Education2012 89 (2), 243-247Biodiesel has gained attention in recent years as a renewable fuel source due to its reduced greenhouse gas and particulate emissions, and it can be produced within the United States. A laboratory experiment designed for students in an upper-division ...
Synthesis of Ibuprofen in the Introductory Organic Laboratory
Richard A. Kjonaas, Peggy E. Williams, David A. Counce, and Lindsey R. CrawleyJournal of Chemical Education2011 88 (6), 825-828Synthesis of Ibuprofen in the Introductory Organic Laboratory
Richard A. Kjonaas, Peggy E. Williams, David A. Counce, and Lindsey R. CrawleyJournal of Chemical Education2011 88 (6), 825-828A method for the synthesis of ibuprofen in introductory organic chemistry laboratory courses is reported. This experiment requires two 3-h lab sessions. All of the reactions and techniques are a standard part of any introductory organic chemistry course. ...
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- Received: August 03, 2009
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