"Greening Up" the Suzuki Reaction

Evangelos Aktoudianakis , Elton Chan , Amanda R. Edward , Isabel Jarosz , Vicki Lee , Leo Mui , Sonya S. Thatipamala and Andrew P. Dicks
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada
J. Chem. Educ., 2008, 85 (4), p 555
DOI: 10.1021/ed085p555
Publication Date (Web): April 1, 2008

Abstract

This article describes the rapid, green synthesis of a biaryl compound (4-phenylphenol) via a Pd(0)-catalyzed Suzuki cross-coupling reaction in water. Mild reaction conditions and operational simplicity makes this experiment especially amenable to both mid- and upper-level undergraduates. The methodology exposes students to purely aqueous microscale organic reactivity and showcases topical research in the milieu of an industrially applicable process.

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  • Received: August 03, 2009

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