Cart
Article
Disulfiram, Metals, and Melanoma
Hi-Res PDFPurchase the full-text
- PDF/HTML,
figures/images,
references and tables,
(where available)
Abstract
A two-session general chemistry laboratory experiment is described concerning redox transformations of disulfiram, the disulfide of diethyldithiocarbamate (deDTC), related to its use in clinical trials for treatment of melanoma. In this laboratory, the students follow three different procedures to synthesize the complex Cu(deDTC)2 using sodium diethyldithiocarbamate, Na(deDTC)·3H2O; disulfiram, DSF; and an oxidized analogue, bis(dialkyliminium) tetrathiolane dication, (bitt-4)2+, as starting materials. The first method is essentially quantitative and has been used as an analytic method for trace metal detection as characterized by colorimetric analysis. The Zn, Ni, and Fe complexes are also synthesized and spectrally characterized. The latter two pathways involve redox disproportionation reactions of the sulfur compounds in which the stoichiometric ratios are obtained by balancing equations. Precipitation analysis is also used to qualitatively identify byproducts of the disproportionation reactions.
Citing Articles
Citation data is made available by participants in CrossRef's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in SciFinder.
This article has been cited by 1 ACS Journal articles (1 most recent appear below).
Molecular Models of Metal Complexes of Dithiocarbamates
William F. ColemanJournal of Chemical Education2009 86 (10), 1248Molecular Models of Metal Complexes of Dithiocarbamates
William F. ColemanJournal of Chemical Education2009 86 (10), 1248
Tools
-
Add to Favorites
-
Download Citation
-
Email a Colleague -
Permalink
Order Reprints
Rights & Permissions
Citation Alerts
SciFinder Links
Explore by:
History
- Received: August 03, 2009
ACS
Network
Facebook
Tweet This
CiteULike
Newsvine
Digg This
Delicious
C−(fc)n−C
