Prev. Article Next Article Table of Contents

Article

Synthesis of Superoxide Dismutase (SOD) Enzyme Mimetics. A Bioinorganic Laboratory Experiment

Supporting Info

Graziella Vecchio and Valeria Lanza

Dipartimento di Scienze Chimiche, Università di Catania, viale A. Doria 8 95125, Catania, Italy

J. Chem. Educ., 2009, 86 (12), p 1419

DOI: 10.1021/ed086p1419

Publication Date (Web): December 1, 2009

Abstract

The study of mimetics of metalloenzymes is a fascinating field. In the light of the clinical data surrounding the use of the superoxide dismutase enzymes, low molecular mass mimics of superoxide dismutase enzymes have recently been proposed for the treatment of a variety of diseases. We propose the synthesis of the manganese(III) complex of N,N'-bis(salicylidene)ethane-1,2-diamine ligand (H₂salen)and the investigation on its superoxide dismutase ability by an indirect assay. This laboratory project was one component of a semester-long advanced undergraduate laboratory course in bioinorganic chemistry and could be expanded using several complementary techniques to characterize the ligand, the metal complex, or to investigate other activities shown by this class of complexes.

View: Hi-Res PDF | PDF w/ Links

Tools

SciFinder Links

Explore by:

Author of this Article Any Author Research Topic

History

Received: August 03, 2009

Recommend & Share

Related Content

The Trans Effect: A Guided-Inquiry Experiment for Upper-Division Inorganic ChemistryJournal of Chemical Education
- The Trans Effect: A Guided-Inquiry Experiment for Upper-Division Inorganic Chemistry
  Janet L. Shaw , Christopher R. Dockery , Scott E. Lewis , Lindsay Harris and Richard Bettis
  Journal of Chemical Education 2009 86 (12), p 1416
  Abstract:
  This article describes a guided-inquiry laboratory for upper-division inorganic chemistry. The experiment is designed to teach students about the trans effect through synthesis of the cis and trans geometric isomers of diamminedichloroplatinum(II). ...
  Abstract | PDF w/ Links | Hi-Res PDF
New Bouncing Curved Arrow Technique for the Depiction of Organic MechanismsJournal of Chemical Education
- New Bouncing Curved Arrow Technique for the Depiction of Organic Mechanisms
  Andrei R. Straumanis , Suzanne M. Ruder
  Journal of Chemical Education 2009 86 (12), p 1389
  Abstract:
  Many students fail to develop a conceptual understanding of organic chemistry. Evidence suggests this failure goes hand-in-hand with a failure to grasp the techniques, meaning, and usefulness of curved arrow notation. Use of curved arrow notation to ...
  Abstract | PDF w/ Links | Hi-Res PDF
Using Proteins in a Bioinorganic Laboratory Experiment: Iron Loading and Removal from TransferrinJournal of Chemical Education
- Using Proteins in a Bioinorganic Laboratory Experiment: Iron Loading and Removal from Transferrin
  David H. Hamilton , Erin E. Battin , Ashley Lawhon and Julia L. Brumaghim
  Journal of Chemical Education 2009 86 (8), p 969
  Abstract:
  With the increasing availability of metalloproteins it is now possible to incorporate them into bioinorganic laboratory experiments. Thus, we have developed a laboratory experiment where students use UV–vis spectroscopy to determine the rate of iron ...
  Abstract | PDF w/ Links | Hi-Res PDF

1155 Sixteenth Street N.W., Washington, DC 20036

ACS Publications is a partner of:

Technology Partner - Atypon Systems, Inc.

#qs-wrap {display: none !important;}

Because you do not have JavaScript enabled, the Quick Search functionality is not displayed here. Please enable JavaScript or use the Advanced Search Page.

Article

Synthesis of Superoxide Dismutase (SOD) Enzyme Mimetics. A Bioinorganic Laboratory Experiment

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

The Trans Effect: A Guided-Inquiry Experiment for Upper-Division Inorganic Chemistry

New Bouncing Curved Arrow Technique for the Depiction of Organic Mechanisms

Using Proteins in a Bioinorganic Laboratory Experiment: Iron Loading and Removal from Transferrin

JOURNALS

BOOKS

MAGAZINE

COMMUNITIES

DIRECTORIES & DATABASES