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A Safer, Discovery-Based Nucleophilic Substitution Experiment

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Gail Horowitz

Department of Chemistry, Yeshiva University, New York, NY 10033

J. Chem. Educ., 2009, 86 (3), p 363

DOI: 10.1021/ed086p363

Publication Date (Web): March 1, 2009

Section:

History, Education, and Documentation

Abstract

A discovery-based nucleophilic substitution experiment is described in which students compare the reactivity of chloride and iodide ions in an S_N2 reaction. This experiment improves upon the well-known "Competing Nucleophiles" experiment in that it does not involve the generation of hydrogen halide gas. The experiment also introduces students to the subject of phase-transfer catalysis.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Laboratory Instruction

Keywords (Pedagogy):

Inquiry-Based / Discovery Learning

Keywords (Subject):

Catalysis

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This article has been cited by 2 ACS Journal articles (2 most recent appear below).

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