Synthesis and Structure of Silver Complexes with Nicotinate-Type Ligands Having Antibacterial Activities against Clinically Isolated Antibiotic Resistant Pathogens

Morsy A. M. Abu-Youssef,*† Raja Dey,‡ Yousry Gohar,§ Alshima'a A. Massoud,† Lars Öhrström,*‡ and Vratislav Langer‡
Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden, Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahimia, 21321 Alexandria, Egypt, and Department of Microbiology, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahimia, 21321 Alexandria, Egypt
Inorg. Chem., 2007, 46 (15), pp 5893–5903
DOI: 10.1021/ic0621594
Publication Date (Web): June 28, 2007
Copyright © 2007 American Chemical Society
*

 To whom correspondence should be addressed. E-mail:  morsy5@link.net (M.A.M.A.-Y.), ohrstrom@chalmers.se (L.Ö). Fax:  +46 31 772 3858 (L.Ö). Phone:  +31 772 2871 (L.Ö).

,
†

 Department of Chemistry, Alexandria University. E-mail:  shimo@chalmers.se (A.A.M.).

,
‡

 Chalmers University of Technology. E-mail:  rdey@usc.edu (R.D.), langer@chalmers.se (V.L.).

,
§

 Department of Microbiology, Alexandria University. E-mail:  ymgohar@yahoo.com (Y.G.).

Abstract

Abstract Image

The synthesis and low-temperature X-ray crystal structures of five new silver complexes, [Ag2-μ-O,O‘(2-aminonicotinium)2(NO3)2]n (7), [Ag(isonicotinamide)2-μ-O,O‘(NO3)]2 (8), [Ag(ethyl nicotinate)2](NO3) (9), [Ag(ethyl isonicotinate)2(NO3)] (10), and [Ag(methyl isonicotinate)2(H2O)](NO3) (11), are presented and fully characterized by spectral and elemental analysis. The antimicrobial activities of these complexes were screened using 12 different clinical isolates belonging to four pathogenic bacteria, S. aureus, S. pyogenes, P. mirabilis, and Ps. Aeruginosa, all obtained from diabetic foot ulcers. These tested bacteria were resistant for at least 10 antibiotics commonly used for treatment of diabetic foot ulcers. Compounds 7 and 8 had considerable activity against Ps. Aeruginosa (MIC values 2−8 μg/mL), compound 9 against S. aureus (MIC 4−16 μg/mL) and S. pyogenes (MIC 2−4 μg/mL), and also 9 and 11 against P. mirabilis (MIC 1−16 μg/mL). All complexes were non-toxic for daphnia at concentrations above 512 μg/mL overnight.

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History

  • Published In Issue July 23, 2007
  • Received November 14, 2006

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