A convergent general synthetic protocol for construction of spirocyclic ketal ionophores: an application to the total synthesis of (-)-A-23187 (calcimycin)

Related Content

• Synthesis of the C1−C52 Fragment of Amphidinol 3, Featuring a β-Alkoxy Alkyllithium Addition ReactionOrganic Letters

  • Synthesis of the C1−C52 Fragment of Amphidinol 3, Featuring a β-Alkoxy Alkyllithium Addition Reaction

    John R. Huckins, Javier de Vicente, and Scott D. Rychnovsky
    Organic Letters 2007 9 (23), pp 4757–4760

    Abstract: An advanced intermediate for the synthesis of amphidinol 3 has been prepared. A cross-metathesis reaction was used to couple the C1−C12 and C13−C26 segments. An unusual β-alkoxy alkyllithium reagent was generated from this segment and added to a Weinreb ...

    Abstract | Full Text HTML | Hi-Res PDF
• Enantioselective Intramolecular Friedel−Crafts-Type α-Arylation of AldehydesJournal of the American Chemical Society

  • Enantioselective Intramolecular Friedel−Crafts-Type α-Arylation of Aldehydes

    K. C. Nicolaou, Rdiger Reingruber, David Sarlah and Stefan Brse
    Journal of the American Chemical Society 2009 131 (6), pp 2086–2087

    Abstract: Enantioselective organo-SOMO catalysis has, in the last two years, been the subject of considerable development and exploration. A number of new and unique transformations have been reported, such as α-allylation, α-oxyamination, α-enolation, and α-...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
• Inspirations, Discoveries, and Future Perspectives in Total SynthesisThe Journal of Organic Chemistry

  • Inspirations, Discoveries, and Future Perspectives in Total Synthesis

    K. C. Nicolaou
    The Journal of Organic Chemistry 2009 74 (3), pp 951–972

    Abstract: The last one hundred years have witnessed a dramatic increase in the power and reach of total synthesis. The pantheon of accomplishments in the field includes the total synthesis of molecules of unimaginable beauty and diversity such as the four ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

Other ACS content by these authors:

• Robert K. Boeckman
• Andre B. Charette
• Theodros Asberom
• Brian H. Johnston