Isolation and structure of bryostatin 1

Related Content

• Synthesis of a Ring-Expanded Bryostatin AnalogueJournal of the American Chemical Society

  • Synthesis of a Ring-Expanded Bryostatin Analogue

    Barry M. Trost, Hanbiao Yang, Oliver R. Thiel, Alison J. Frontier, and Cheyenne S. Brindle
    Journal of the American Chemical Society 2007 129 (8), pp 2206–2207

    Abstract: A ring-expanded bryostatin analogue was synthesized by utilizing a Ru-catalyzed tandem tetrahydropyran formation, a Pd-catalyzed tandem dihydropyran formation, and a ring-closing metathesis (RCM) as key steps. The analogue possesses potent antitumor ...

    Abstract | Full Text HTML | Hi-Res PDF
• Total Synthesis of Bryostatin 2Journal of the American Chemical Society

  • Total Synthesis of Bryostatin 2

    David A. Evans, Percy H. Carter, Erick M. Carreira, André B. Charette, Joëlle A. Prunet, and Mark Lautens
    Journal of the American Chemical Society 1999 121 (33), pp 7540–7552

    Abstract: The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present in each of the principal subunits (A, B, and C). These fragments ...

    Abstract | Full Text HTML | Hi-Res PDF
• The Practical Synthesis of a Novel and Highly Potent Analogue of BryostatinJournal of the American Chemical Society

  • The Practical Synthesis of a Novel and Highly Potent Analogue of Bryostatin

    Paul A. Wender, Jeremy L. Baryza, Chad E. Bennett, F. Christopher Bi, Stacey E. Brenner, Michael O. Clarke, Joshua C. Horan, Cindy Kan, Emmanuel Lacôte, Blaise Lippa, Peter G. Nell, and Tim M. Turner
    Journal of the American Chemical Society 2002 124 (46), pp 13648–13649

    Abstract: Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar affinity for PKC and exhibits over 100-fold greater potency than bryostatin 1 when tested ...

    Abstract | Full Text HTML | Hi-Res PDF

Other ACS content by these authors:

• George R. Pettit
• Cherry L. Herald
• Dennis L. Doubek
• Delbert L. Herald
• Edward Arnold
• Jon Clardy