Synthesis of deoxyoligonucleotides on a polymer support

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• Introduction of 3′-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base ProtectionThe Journal of Organic Chemistry

  • Introduction of 3′-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection

    Akihiro Ohkubo, Yasuhiro Noma, Katsufumi Aoki, Hirosuke Tsunoda, Kohji Seio and Mitsuo Sekine
    The Journal of Organic Chemistry 2009 74 (7), pp 2817–2823

    Abstract: New 3′-terminal deoxyribonucleoside-loading reagents having a silyl-type linker were developed. They were effectively introduced into polymer supports under the conditions of Huisgen [3 + 2] cycloaddition without base protection. Moreover, four ...

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