The Synthesis of Morphine

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This article has been cited by 8 ACS Journal articles (5 most recent appear below).

• 

  Concise Syntheses of (−)-Galanthamine and (±)-Codeine via Intramolecular Alkylation of a Phenol Derivative

  Philip Magnus, Neeraj Sane, Benjamin P. Fauber and Vince Lynch
  Journal of the American Chemical Society2009 131 (44), 16045-16047

  • Concise Syntheses of (−)-Galanthamine and (±)-Codeine via Intramolecular Alkylation of a Phenol Derivative

    Philip Magnus, Neeraj Sane, Benjamin P. Fauber and Vince Lynch
    Journal of the American Chemical Society2009 131 (44), 16045-16047

    Suzuki coupling of 7 to 8 gave the biphenyl derivative 9. Reaction of 9 with ethyl vinyl ether/bromine/base gave 10, which on treatment with CsF/DMF at 130 °C resulted in the cross-conjugated 2,5-cyclohexadienone 6. Acid hydrolysis of 6 gave 11, which was ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  Lewis Acid Catalyzed Diels−Alder Reactions of 1,2-Naphthoquinones

  Danny M. Gelman, Craig M. Forsyth and Patrick Perlmutter
  Organic Letters2009 11 (21), 4958-4960

  • Lewis Acid Catalyzed Diels−Alder Reactions of 1,2-Naphthoquinones

    Danny M. Gelman, Craig M. Forsyth and Patrick Perlmutter
    Organic Letters2009 11 (21), 4958-4960

    The use of BF3·OEt2 catalysis in Diels−Alder reactions of 3,4-unsubstituted 1,2-naphthoquinones provides direct access to cis-tetrahydrophenanthrene derivatives in good to excellent yields (66−99%) without rapid adduct aromatization commonly associated ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  Synthesis of an Estrogen Receptor β-Selective Radioligand:  5-[¹⁸F]Fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile and Comparison of in Vivo Distribution with 16α-[¹⁸F]Fluoro-17β-estradiol

  Jeongsoo Yoo, Carmen S. Dence, Terry L. Sharp, John A. Katzenellenbogen, and Michael J. Welch
  Journal of Medicinal Chemistry2005 48 (20), 6366-6378

  • Synthesis of an Estrogen Receptor β-Selective Radioligand:  5-[¹⁸F]Fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile and Comparison of in Vivo Distribution with 16α-[¹⁸F]Fluoro-17β-estradiol

    Jeongsoo Yoo, Carmen S. Dence, Terry L. Sharp, John A. Katzenellenbogen, and Michael J. Welch
    Journal of Medicinal Chemistry2005 48 (20), 6366-6378

    Estrogen receptor (ER), a less active ER subtype that appears to have a restraining effect on the more active ER, could be a factor that determines the level of estrogen action in certain estrogen target tissues. ER is found in breast cancer, and its ...

    Abstract | Full Text HTML | Hi-Res PDF
• 

  Decoration of the Aromatic Ring of Dihydrocodeinone (Hydrocodone) and 14-Hydroxydihydrocodeinone (Oxycodone)

  Michael L. Wilson, Patrick J. Carroll, and David R. Dalton
  The Journal of Organic Chemistry2005 70 (16), 6492-6495

  • Decoration of the Aromatic Ring of Dihydrocodeinone (Hydrocodone) and 14-Hydroxydihydrocodeinone (Oxycodone)

    Michael L. Wilson, Patrick J. Carroll, and David R. Dalton
    The Journal of Organic Chemistry2005 70 (16), 6492-6495

    Improved protocols for the preparation of 1-bromodihydrocodeinone (1-bromohydrocodone) and 1-bromo-14-hydroxydihydrocodeinone (1-bromooxycodone) and synthesis of the corresponding 1-chloro and 1-iodo derivatives have been achieved using the corresponding ...

    Abstract | Full Text HTML | Hi-Res PDF
• 

  4,5-Diphenyltriazol-3-ones:  Openers of Large-Conductance Ca²⁺-Activated Potassium (Maxi-K) Channels

  Jeffrey L. Romine, Scott W. Martin, Valentin K. Gribkoff, Christopher G. Boissard, Steven I. Dworetzky, Joanne Natale, Yi Li, Qi Gao, Nicholas A. Meanwell, and John E. Starrett, Jr.
  Journal of Medicinal Chemistry2002 45 (14), 2942-2952

  • 4,5-Diphenyltriazol-3-ones:  Openers of Large-Conductance Ca²⁺-Activated Potassium (Maxi-K) Channels

    Jeffrey L. Romine, Scott W. Martin, Valentin K. Gribkoff, Christopher G. Boissard, Steven I. Dworetzky, Joanne Natale, Yi Li, Qi Gao, Nicholas A. Meanwell, and John E. Starrett, Jr.
    Journal of Medicinal Chemistry2002 45 (14), 2942-2952

    A series of diphenyl-substituted heterocycles were synthesized and evaluated by electrophysiological techniques as openers of the cloned mammalian large-conductance, Ca2+-activated potassium (maxi-K) channel. The series was designed from deannulation of ...

    Abstract | Full Text HTML | Hi-Res PDF

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