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Communication

DNA-Catalyzed Polymerization^†

Supporting Info

Xiaoyu Li, Zheng-Yun J. Zhan, Rachel Knipe, and David G. Lynn*

Departments of Chemistry and Biology, Emory University, Emerson Hall, Atlanta, Georgia 30322

J. Am. Chem. Soc., 2002, 124 (5), pp 746–747

DOI: 10.1021/ja017319j

Publication Date (Web): January 12, 2002

†

A portion of this work was initiated at the Department of Chemistry, University of Chicago, Chicago, IL 60637.

Author for correspondence. Telephone: (404) 727-9348. Fax: (404) 727-6586. E-mail: dlynn2@emory.edu.

Abstract

Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5‘-amino-3‘-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.

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Published In Issue February 06, 2002
Received October 17, 2001

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Communication

DNA-Catalyzed Polymerization^†