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Communication

A Copper-Catalyzed C−N Bond Formation Involving sp-Hybridized Carbons. A Direct Entry to Chiral Ynamides via N-Alkynylation of Amides

Supporting Info

Michael O. Frederick, Jason A. Mulder, Michael R. Tracey, Richard P. Hsung,* Jian Huang, Kimberly C. M. Kurtz, Lichun Shen, and Christopher J. Douglas

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455

J. Am. Chem. Soc., 2003, 125 (9), pp 2368–2369

DOI: 10.1021/ja021304j

Publication Date (Web): February 6, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, hsung@chem.umn.edu

Abstract

A copper-catalyzed new C−N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.

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Published In Issue March 05, 2003
Received October 28, 2002

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Communication

A Copper-Catalyzed C−N Bond Formation Involving sp-Hybridized Carbons. A Direct Entry to Chiral Ynamides via N-Alkynylation of Amides

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Enantiospecific Total Syntheses of Kapakahines B and F

Palladium-Catalyzed Asymmetric Dearomatization of Naphthalene Derivatives

Copper Sulfate-Pentahydrate-1,10-Phenanthroline Catalyzed Amidations of Alkynyl Bromides. Synthesis of Heteroaromatic Amine Substituted Ynamides

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