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Enantioselective Direct-Addition of Terminal Alkynes to Imines Catalyzed by Copper(I)pybox Complex in Water and in Toluene
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Abstract
Highly enantioselective direct alkyne−imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield.
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This article has been cited by 70 ACS Journal articles (5 most recent appear below).
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Courtney E. Meyet, Conor J. Pierce, and Catharine H. LarsenOrganic Letters2012 Article ASAPA single Cu(II) catalyst without the addition of ligand or base couples a diverse range of nitrogen sources with alkynes and aldehydes bearing alkyl, halogenated, silyl, aryl, and heteroaryl groups. The first example of a copper-catalyzed alkynylation ...
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Palladium-Catalyzed Oxidative Alkynylation of Heterocycles with Terminal Alkynes under Air Conditions
Seok Hwan Kim, Jungho Yoon, and Sukbok ChangOrganic Letters2011 13 (6), 1474-1477Palladium-Catalyzed Oxidative Alkynylation of Heterocycles with Terminal Alkynes under Air Conditions
Seok Hwan Kim, Jungho Yoon, and Sukbok ChangOrganic Letters2011 13 (6), 1474-1477Pd-Catalyzed oxidative alkynylation of azoles with terminal alkynes was developed via simultaneous activation of both heterocyclic sp2 C−H and alkynyl sp C−H bonds. The choice of palladium catalyst source and external base resulted in being important ...
Direct C−H Transformation via Iron Catalysis
Chang-Liang Sun, Bi-Jie Li, and Zhang-Jie ShiChemical Reviews2011 111 (3), 1293-1314Direct C−H Transformation via Iron Catalysis
Chang-Liang Sun, Bi-Jie Li, and Zhang-Jie ShiChemical Reviews2011 111 (3), 1293-1314
Fe3O4 Nanoparticle-Supported Copper(I) Pybox Catalyst: Magnetically Recoverable Catalyst for Enantioselective Direct-Addition of Terminal Alkynes to Imines
Tieqiang Zeng, Luo Yang, Reuben Hudson, Gonghua Song, Audrey R. Moores, and Chao-Jun LiOrganic Letters2011 13 (3), 442-445Fe3O4 Nanoparticle-Supported Copper(I) Pybox Catalyst: Magnetically Recoverable Catalyst for Enantioselective Direct-Addition of Terminal Alkynes to Imines
Tieqiang Zeng, Luo Yang, Reuben Hudson, Gonghua Song, Audrey R. Moores, and Chao-Jun LiOrganic Letters2011 13 (3), 442-445An Fe3O4 nanoparticle-supported copper(I) pybox catalyst, which exhibits excellent reactivity and yields products with good enantioselectivity, was developed. As a proof of concept, six optically active propargyl amines were obtained in excellent ...
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History
- Published In Issue May 22, 2002
- Received February 22, 2002
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