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Communication

The Catalytic Asymmetric Mannich-Type Reactions in Aqueous Media

Supporting Info

Shū Kobayashi,* Tomoaki Hamada, and Kei Manabe

Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033 Japan

J. Am. Chem. Soc., 2002, 124 (20), pp 5640–5641

DOI: 10.1021/ja026094p

Publication Date (Web): April 30, 2002

Corresponding author. E-mail: skobayas@mol.f.u-tokyo.ac.jp.

Abstract

The catalytic, diastereo- and enantioselective Mannich-type reaction of a hydrazono ester with silyl enol ethers in aqueous media has been successfully achieved with ZnF₂, a chiral diamine ligand, and trifluoromethanesulfonic acid.

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Published In Issue May 22, 2002
Received March 5, 2002

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Communication

The Catalytic Asymmetric Mannich-Type Reactions in Aqueous Media

Abstract

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History

Recommend & Share

Related Content

Enantio- and Diastereoselective, Stereospecific Mannich-Type Reactions in Water

Catalytic, Asymmetric Mannich-type Reactions of N-Acylimino Esters: Reactivity, Diastereo- and Enantioselectivity, and Application to Synthesis of N-Acylated Amino Acid Derivatives

Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives: Enantioselective Synthesis of β-Aryl-β-Amino Acids

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