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Communication

Total Synthesis of Ecteinascidin 743

Supporting Info

Atsushi Endo, Arata Yanagisawa, Masanao Abe, Shigemitsu Tohma, Toshiyuki Kan, and Tohru Fukuyama*

Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

J. Am. Chem. Soc., 2002, 124 (23), pp 6552–6554

DOI: 10.1021/ja026216d

Publication Date (Web): May 17, 2002

To whom correspondence should be addressed. E-mail: fukuyama@ mol.f.u-tokyo.ac.jp.

Abstract

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol−aldehyde cyclization, and acid-induced intramolecular sulfide formation.

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Published In Issue June 12, 2002
Received March 18, 2002

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Communication

Total Synthesis of Ecteinascidin 743

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Enantioselective Total Synthesis of Ecteinascidin 743

Enantioselective Total Synthesis of (−)-Napyradiomycin A1 via Asymmetric Chlorination of an Isolated Olefin

A Short and Efficient Synthesis of (−)-7-Methylomuralide, a Potent Proteasome Inhibitor

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