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A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening

Department of Chemistry, New York University, New York, New York 10003, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, and Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109
J. Am. Chem. Soc., 2002, 124 (39), pp 11608–11609
DOI: 10.1021/ja026720i
Publication Date (Web): September 10, 2002
Copyright © 2002 American Chemical Society

Abstract

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The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

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Article Views: 1,556 Times
Received 2 May 2002
Published online 10 September 2002
Published in print 1 October 2002
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