Dedifferentiation of Lineage-Committed Cells by a Small Molecule

Shuibing Chen, Qisheng Zhang, Xu Wu, Peter G. Schultz,* and Sheng Ding*;
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037
J. Am. Chem. Soc., 2004, 126 (2), pp 410–411
DOI: 10.1021/ja037390k
Publication Date (Web): December 19, 2003
Copyright © 2004 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, sding@scripps.edu, ; , schultz@scripps.edu

Abstract

Abstract Image

Combinatorial libraries were screened for molecules that induce mouse myogenic lineage committed cells to dedifferentiate in vitro. A 2,6-disubstituted purine, reversine, was discovered that induces lineage reversal of C2C12 cells to become multipotent progenitor cells which can redifferentiate into osteoblasts and adipocytes. This and other such molecules are likely to provide new insights into the molecular mechanisms that control cellular dedifferentiation and may ultimately be useful to in vivo stem cell biology and therapy.

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History

  • Published In Issue January 21, 2004
  • Received July 18, 2003

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