A General Method for the Suzuki−Miyaura Cross-Coupling of Sterically Hindered Aryl Chlorides:  Synthesis of Di- and Tri-ortho-substituted Biaryls in 2-Propanol at Room Temperature

Oscar Navarro, Roy A. Kelly, III, and Steven P. Nolan*
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148
J. Am. Chem. Soc., 2003, 125 (52), pp 16194–16195
DOI: 10.1021/ja038631r
Publication Date (Web): December 9, 2003
Copyright © 2003 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, snolan@uno.edu

Abstract

Abstract Image

The catalytic formation of di- and trisubstituted ortho biaryl junctions has been achieved using a palladacylce pre-catalyst bearing a N-heterocyclic carbene ligand. This transformation is performed at room temperature in technical grade 2-propanol.

Tools

History

  • Published In Issue December 31, 2003
  • Received September 20, 2003

Recommend & Share

Related Content

Other ACS content by these authors: