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Communication

Cross-Couplings of Alkyl Electrophiles under “Ligandless” Conditions: Negishi Reactions of Organozirconium Reagents

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Sheryl L. Wiskur, Alexander Korte, and Gregory C. Fu*

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

J. Am. Chem. Soc., 2004, 126 (1), pp 82–83

DOI: 10.1021/ja0393729

Publication Date (Web): December 16, 2003

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, gcf@mit.edu

Abstract

This report establishes that simple, “ligandless” palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.

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Published In Issue January 14, 2004
Received November 1, 2003

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Communication

Cross-Couplings of Alkyl Electrophiles under “Ligandless” Conditions: Negishi Reactions of Organozirconium Reagents

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Cross-Couplings of Unactivated Secondary Alkyl Halides: Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides

The First Applications of Carbene Ligands in Cross-Couplings of Alkyl Electrophiles: Sonogashira Reactions of Unactivated Alkyl Bromides and Iodides

Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides

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