Cationic Carbon Nanotubes Bind to CpG Oligodeoxynucleotides and Enhance Their Immunostimulatory Properties

Alberto Bianco,* Johan Hoebeke, Sylvie Godefroy, Olivier Chaloin, Davide Pantarotto, Jean-Paul Briand, Sylviane Muller, Maurizio Prato,* and Charalambos D. Partidos*;
Institut de Biologie Molculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thrapeutiques, 67084 Strasbourg, France, and Dipartimento di Scienze Farmaceutiche, Universit di Trieste, 34127 Trieste, Italy
J. Am. Chem. Soc., 2005, 127 (1), pp 58–59
DOI: 10.1021/ja044293y
Publication Date (Web): December 16, 2004
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,

 Institut de Biologie Moléculaire et Cellulaire.

,

 Università di Trieste.

, A.Bianco@ibmc.u-strasbg.fr, ; , H.Partidos@ibmc.u-strasbg.fr

Abstract

Abstract Image

Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs.

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History

  • Published In Issue January 12, 2005
  • Received September 20, 2004

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