Spirodiepoxides in Total Synthesis:  Epoxomicin

Related Content

• A Spirodiepoxide-Based Strategy to the A−B Ring System of Pectenotoxin 4Organic Letters

  • A Spirodiepoxide-Based Strategy to the A−B Ring System of Pectenotoxin 4

    Stephen D. Lotesta, Yongquan Hou, and Lawrence J. Williams
    Organic Letters 2007 9 (5), pp 869–872

    Abstract: A synthesis of a pectenotoxin 4 C1−C15 segment is reported. Suitable C1−C7 and C8−C15 segments were prepared, coupled, converted to I and the C3-hydroxy variant, and then cyclized. Key findings include the stereoselective conversion of the allene to the ...

    Abstract | Full Text HTML | Hi-Res PDF
• Spirodiepoxide Reaction with CupratesJournal of the American Chemical Society

  • Spirodiepoxide Reaction with Cuprates

    Partha Ghosh, Stephen D. Lotesta, and Lawrence J. Williams
    Journal of the American Chemical Society 2007 129 (9), pp 2438–2439

    Abstract: The first example of transition-metal-mediated transformations of spirodiepoxides and the first general method for carbon−carbon bond formation using the spirodiepoxide functional group are reported. Organocopper-mediated addition to spirodiepoxides gives ...

    Abstract | Full Text HTML | Hi-Res PDF
• Total Synthesis of (+)-Cyanthiwigin UJournal of the American Chemical Society

  • Total Synthesis of (+)-Cyanthiwigin U

    Matthew W. B. Pfeiffer and Andrew J. Phillips
    Journal of the American Chemical Society 2005 127 (15), pp 5334–5335

    Abstract: A concise total synthesis of the tricyclic terpene cyanthiwigin U has been accomplished in 12 steps and 17% overall yield. The key step of the synthesis is a two-directional tandem metathesis reaction that forms the cyclohepta[e]indene core from a readily ...

    Abstract | Full Text HTML | Hi-Res PDF

Other ACS content by these authors:

• Sreenivas Katukojvala
• Kristin N. Barlett
• Stephen D. Lotesta
• Lawrence J. Williams