Communication
Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Acyclic Enones
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

A highly enantioselective Cu-catalyzed addition of Grignard reagents to acyclic aliphatic enones is described. In the presence of 5 mol % of CuBr·SMe2 and 6 mol % of JosiPhos diphosphine aliphatic enones react with Grignard reagents to provide β-substituted linear ketones with high yields, regio-, and enantioselectivities.
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History
- Published In Issue October 13, 2004
- Received June 8, 2004
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