Intramolecular Cyclopropanation of Unsaturated Terminal Epoxides

David M. Hodgson,* Ying Kit Chung, and Jean-Marc Paris†
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.
J. Am. Chem. Soc., 2004, 126 (28), pp 8664–8665
DOI: 10.1021/ja047346k
Publication Date (Web): June 24, 2004
Copyright © 2004 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
†

 Rhodia Recherches, Centre de Recherches de Lyon, 85 Avenue des Frères Perret, 69192 Saint Fons, France.

, david.hodgson@chem.ox.ac.uk

Abstract

Abstract Image

Efficient lithium amide-induced intramolecular cyclopropanation of bishomoallylic and trishomoallylic epoxides is described. The methodology is used in an asymmetric synthesis of sabina ketone.

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History

  • Published In Issue July 21, 2004
  • Received May 6, 2004

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