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Communication

Biaryl Synthesis via Direct Arylation: Establishment of an Efficient Catalyst for Intramolecular Processes

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Louis-Charles Campeau, Mathieu Parisien, Melissa Leblanc, and Keith Fagnou*

Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5

J. Am. Chem. Soc., 2004, 126 (30), pp 9186–9187

DOI: 10.1021/ja049017y

Publication Date (Web): July 10, 2004

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, keith.fagnou@science.uottawa.ca

Abstract

In this Communication, we describe direct arylation reactions with improved scope and catalyst activity for the intramolecular formation of biaryl compounds. This was achieved through the establishment of a highly active and robust catalyst system and the subsequent development of a novel phosphine ligand 27. The enhanced catalytic activity extends these transformations to include previously unreactive and poorly reactive substrates, and allows for very low catalyst loadings to be employedas little as 0.1 mol %.

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Published In Issue August 04, 2004
Received February 20, 2004

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Communication

Biaryl Synthesis via Direct Arylation: Establishment of an Efficient Catalyst for Intramolecular Processes

Abstract

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SciFinder Links

History

Recommend & Share

Related Content

Catalytic Direct Arylation with Aryl Chlorides, Bromides, and Iodides: Intramolecular Studies Leading to New Intermolecular Reactions Catalytic Direct Arylation with Aryl Chlorides, Bromides, and Iodides: Intramolecular Studies Leading to New Intermolecular Reactions

Palladium-Catalyzed Benzene Arylation: Incorporation of Catalytic Pivalic Acid as a Proton Shuttle and a Key Element in Catalyst Design Palladium-Catalyzed Benzene Arylation: Incorporation of Catalytic Pivalic Acid as a Proton Shuttle and a Key Element in Catalyst Design

Elements of Regiocontrol in Palladium-Catalyzed Oxidative Arene Cross-Coupling

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