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Communication

Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines

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Jens Paetzold and Jan E. Bäckvall*

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691 Stockholm, Sweden

J. Am. Chem. Soc., 2005, 127 (50), pp 17620–17621

DOI: 10.1021/ja056306t

Publication Date (Web): November 19, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, jeb@organ.su.se

Abstract

An efficient process for dynamic kinetic resolution of amines was developed by combining a ruthenium-catalyzed racemization with a lipase-catalyzed resolution. A variety of unfunctionalized primary amines were transformed into one enantiomer of the amide in high yield and high enantioselectivity.

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Published In Issue December 21, 2005
Received September 13, 2005

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Communication

Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines

Abstract

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History

Recommend & Share

Related Content

Combination of Enzymes and Metal Catalysts. A Powerful Approach in Asymmetric Catalysis

Combined Ruthenium(II) and Lipase Catalysis for Efficient Dynamic Kinetic Resolution of Secondary Alcohols. Insight into the Racemization Mechanism

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