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Communication

Three-Dimensional Chiral Imaging by Sum-Frequency Generation

Supporting Info

Na Ji,^† Kai Zhang,^‡ Haw Yang,*^‡ and Yuen-Ron Shen*^†;

Department of Physics and Department of Chemistry, University of California at Berkeley, Berkeley, California 94720

J. Am. Chem. Soc., 2006, 128 (11), pp 3482–3483

DOI: 10.1021/ja057775y

Publication Date (Web): February 22, 2006

†

Department of Physics.

‡

Department of Chemistry.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, hawyang@berkeley.edu, ; , yrshen@calmail.berkeley.edu

Abstract

A sum-frequency generation (SFG) microscope that is sensitive toward molecular chirality was demonstrated for the first time. Optically active images of chiral 1,1‘-bi-2-naphthol solutions were obtained with submicron spatial resolution. Three-dimensional sectioning capability of our microscope was also demonstrated. This optically active SFG microscopy can potentially become a powerful imaging technique for biological samples.

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