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Communication

Highly Enantioselective Addition of Me₂Zn to Aldehydes Catalyzed by ClCr(Salen)

Supporting Info

Pier Giorgio Cozzi* and Peter Kotrusz

Dipartimento di Chimica, University of Bologna, G. Ciamician, via Selmi 2, 40126 Bologna, Italy

J. Am. Chem. Soc., 2006, 128 (15), pp 4940–4941

DOI: 10.1021/ja057969d

Publication Date (Web): March 24, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, piergiorgio.cozzi@unibo.it

Abstract

High enantiomeric excesses are obtained in the addition of Me₂Zn catalyzed by commercially available ClCr(Salen). Broad scope, simple procedure, room temperature, low catalyst loading are the characteristics of this new enantioselective process, which uses the rather unreactive Me₂Zn. Enantiomeric excesses in the range of 71−99% are obtained with all the aldehydes tested.

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Published In Issue April 19, 2006
Received November 23, 2005

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Communication

Highly Enantioselective Addition of Me₂Zn to Aldehydes Catalyzed by ClCr(Salen)