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A Chemo-Enzymatic Route to Enantiomerically Pure Cyclic Tertiary Amines
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Abstract
Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.
Citing Articles
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This article has been cited by 14 ACS Journal articles (5 most recent appear below).
Catalytic Kinetic Resolution of Cyclic Secondary Amines
Michael Binanzer, Sheng-Ying Hsieh, and Jeffrey W. BodeJournal of the American Chemical Society2011 133 (49), 19698-19701Catalytic Kinetic Resolution of Cyclic Secondary Amines
Michael Binanzer, Sheng-Ying Hsieh, and Jeffrey W. BodeJournal of the American Chemical Society2011 133 (49), 19698-19701The catalytic resolution of racemic cyclic amines has been achieved by an enantioselective amidation reaction featuring an achiral N-heterocyclic carbene catalyst and a new chiral hydroxamic acid cocatalyst working in concert. The reactions proceed at ...
Engineering a Biometallic Whole Cell Catalyst for Enantioselective Deracemization Reactions
Joanne M. Foulkes, Kirk J. Malone, Victoria S. Coker, Nicholas J. Turner, and Jonathan R. LloydACS Catalysis2011 1 (11), 1589-1594Engineering a Biometallic Whole Cell Catalyst for Enantioselective Deracemization Reactions
Joanne M. Foulkes, Kirk J. Malone, Victoria S. Coker, Nicholas J. Turner, and Jonathan R. LloydACS Catalysis2011 1 (11), 1589-1594The ability of microbial cells to synthesize highly reactive nanoscale functional materials provides the basis for a novel synthetic biology tool for developing the next generation of multifunctional industrial biocatalysts. Here, we demonstrate that ...
Enantioselective Oxidation of C–O and C–N Bonds Using Oxidases
Nicholas J. TurnerChemical Reviews2011 111 (7), 4073-4087Enantioselective Oxidation of C–O and C–N Bonds Using Oxidases
Nicholas J. TurnerChemical Reviews2011 111 (7), 4073-4087
Application of Designed Enzymes in Organic Synthesis
Gernot A. Strohmeier, Harald Pichler, Oliver May, and Mandana Gruber-KhadjawiChemical Reviews2011 111 (7), 4141-4164Application of Designed Enzymes in Organic Synthesis
Gernot A. Strohmeier, Harald Pichler, Oliver May, and Mandana Gruber-KhadjawiChemical Reviews2011 111 (7), 4141-4164
Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases
Matthew D. Truppo, J. David Rozzell and Nicholas J. TurnerOrganic Process Research & Development2010 14 (1), 234-237Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases
Matthew D. Truppo, J. David Rozzell and Nicholas J. TurnerOrganic Process Research & Development2010 14 (1), 234-237Two methods for the efficient (50 g/L) production of optically pure amines from their corresponding ketones using transaminases have been developed. The first method utilizes an ion-exchange resin for in situ product removal allowing the reaction to be ...
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History
- Published In Issue February 22, 2006
- Received December 16, 2005
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