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Communication
Room Temperature Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes
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J. Am. Chem. Soc., 2006, 128 (13), pp 4246–4247
DOI: 10.1021/ja060126h
Publication Date (Web): March 14, 2006
Copyright © 2006 American Chemical Society
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, fmichael@chem.washington.eduIn papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits β-hydride elimination.
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History
- Published In Issue April 05, 2006
- Received January 6, 2006
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