Interfacing Carbon Nanotubes with Living Cells

Xing Chen,†# Un Chong Tam,† Jennifer L. Czlapinski,† Goo Soo Lee,†# David Rabuka,† Alex Zettl,*‡# and Carolyn R. Bertozzi*†§;
Departments of Chemistry, Physics and Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720
J. Am. Chem. Soc., 2006, 128 (19), pp 6292–6293
DOI: 10.1021/ja060276s
Publication Date (Web): April 21, 2006
Copyright © 2006 American Chemical Society
†

 Department of Chemistry, University of California, Berkeley.

,
#

 Lawrence Berkeley National Laboratory.

,
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

,
‡

 Department of Physics, University of California, Berkeley.

,
§

 Department of Molecular and Cell Biology, University of California, Berkeley.

,

 Howard Hughes Medical Institute, University of California, Berkeley.

, azettl@socrates.berkeley.edu, ; , crb@berkeley.edu

Abstract

Abstract Image

We developed a polymer coating for carbon nanotubes (CNTs) that mimics the mucin glycoprotein coating of mammalian cells. CNTs coated with these mucin mimic polymers have two novel properties:  they can bind to carbohydrate receptors, providing a means for biomimetic interactions with cell surfaces, and, importantly, they are rendered nontoxic to cells.

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History

  • Published In Issue May 17, 2006
  • Received January 13, 2006

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