Contrast Agents for Magnetic Resonance Imaging Synthesized with Ring-Opening Metathesis Polymerization

Matthew J. Allen, Ronald T. Raines, and Laura L. Kiessling*
Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706
J. Am. Chem. Soc., 2006, 128 (20), pp 6534–6535
DOI: 10.1021/ja061383p
Publication Date (Web): May 3, 2006
Copyright © 2006 American Chemical Society

Abstract

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A monomer for ring-opening metathesis polymerization (ROMP) has been developed that also functions as a portion of a GdIII chelating moiety for a magnetic resonance imaging contrast agent. An increase in per GdIII relaxivity was shown upon transition from monomer to polymer. Additionally, extremely large molecular relaxivities were achieved through incorporation of multiple GdIII ions per polymer. The nature of ROMP-derived polymers allows for functionalization of the monomer units and termini through orthogonal chemistry. This strategy is the basis for a new class of highly sensitive, targeted imaging agents.

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History

  • Published In Issue May 24, 2006
  • Received February 27, 2006

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