Cleavage of a Carbon−Carbon Triple Bond via Gold-Catalyzed Cascade Cyclization/Oxidative Cleavage Reactions of (Z)-Enynols with Molecular Oxygen

Yuanhong Liu,* Feijie Song, and Shenghai Guo
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China
J. Am. Chem. Soc., 2006, 128 (35), pp 11332–11333
DOI: 10.1021/ja062610q
Publication Date (Web): August 11, 2006
Copyright © 2006 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, yhliu@mail.sioc.ac.cn

Abstract

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A highly efficient carbon−carbon triple bond cleavage reaction of (Z)-enynols was developed, which offered a new route to highly substituted butenolides. The methodology is realized by a tandem reaction using a single gold(I) catalyst, which could catalyze different reactions of cyclization/oxidative cleavage in the same vessel.

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History

  • Published In Issue September 06, 2006
  • Received April 14, 2006

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